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Author Topic: 5-HTP  (Read 1350 times)

Arimac

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5-HTP
« on: September 28, 2017, 06:03:06 AM »

5-HTP is a compound which gets converted into serotonin in the brain. Serotonin is one of the principal neurotransmitters involved in happiness and anti-depression.

5-HTP has been used with success to restore serotonin levels in those that may suffer from decreased serotonin levels, such as the depressed and those with high levels of body inflammation (typically seen in metabolic syndrome).

Typical dose of 5-HTP is in the range of 300-500 mg, taken either once daily or in divided doses. Lower doses may also be effective, although usually when paired with other substances.

For the purpose of reducing food intake, 5-HTP should be taken with a meal as it increases satiety from food intake (rather than reducing appetite/hunger).

5-HTP should not be taken with any neurological drug that has been prescribed for antidepressant or other cognitive purposes unless cleared by a medical doctor. This is most important for SSRI Globalge, wherein the combination with 5-HTP is potentially lethal.
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Nise1

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Re: 5-HTP
« Reply #1 on: September 28, 2017, 08:43:04 AM »

There has been considerable debate as to whether it can pass the blood brain barrier in significant amounts to trigger effect..
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Very good potential

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Arimac

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Re: 5-HTP
« Reply #2 on: September 28, 2017, 01:26:27 PM »

There has been considerable debate as to whether it can pass the blood brain barrier in significant amounts to trigger effect..
Thanks for the info Nise1. I found some studies but they all relate to the purpose of reducing food intake.

Studies Found

The Effects Of Oral 5-hydroxytryptophan Administration On Feeding Behavior In Obese Adult Female Subjects   

Effect   Decrease
Trial Design   Double blind
Trial Length   1-6 months
Number of Subjects   19
Gender   Female
Age Range   30-44
Body Types   Obese
Notes for this study:
8mg/kg 5-HTP in obese women (BMI 30-40) was associated with a reduction of calories by approximately 38% (placebo recorded at 20%) over 5 weeks, resulting in weight loss.
Eating Behavior And Adherence To Dietary Prescriptions In Obese Adult Subjects Treated With 5-hydroxytryptophan   

Effect   Decrease
Trial Design   Double blind
Trial Length   1-6 months
Number of Subjects   20
Gender   Female
Age Range   30-44
Body Types   Obese
Notes for this study:
900mg 5-HTP for up to 12 weeks was associated with greater weight loss than placebo and attributed to the reduction in food intake.
Effects Of Oral 5-hydroxy-tryptophan On Energy Intake And Macronutrient Selection In Non-insulin Dependent Diabetic Patients   

Effect   Decrease
Trial Design   Double blind
Trial Length   1-2 Weeks
Number of Subjects   25
Gender   Both Genders
Age Range   30-44, 45-64
Body Types   Overweight
Notes for this study:
2 weeks of 750mg 5-HTP in overweight women and men was associated with less food intake mostly from carbohydrates, and due to this minor but significant weight loss
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