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Author Topic: Creatine Myostatin Study (ON INHIBITING MYOSTATIN) would be this TRUE ?  (Read 1506 times)

MAGOBARDO

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Creatine Myostatin Study
Your muscles have a variety of enemies that work to hold you back from making the gains you want and keep you stuck in the status quo. You are probably aware of some of them ? eating wrong, not getting enough sleep, catabolism, etc., but may not be aware of others.
One of those enemies that falls into the relatively unknown camp is myostatin, a substance most people are not familiar with. Ask the average person in the gym what myostatin is and they probably can?t tell you.
Myostatin binds to muscle cells and acts to impair muscle growth. How? It shuts down protein synthesis. Protein synthesis is needed for your muscles to not only get the green light to grow but also to fuel that growth. Myostatin takes it upon itself to short-circuit that process. In fact it acts strongly in this manner, actually working to destroy the muscle. Myostatin = muscle destruction. So myostatin is one nasty enemy.
If you are into building muscle, you recognize that myostatin?s actions must be stopped if you want to maximize your own muscle growth.
Creatine the champ
Fortunately there is a substance that hits back at myostatin. And better yet, it comes in supplement form. Research indicates that creatine does in fact inhibit myostatin.
A study published in Molecular and Cellular Endocrinology found that study subjects who ingested creatine for two months straight exhibited significantly lower secretions of myostatin than subjects on a placebo. While myostatin may be a muscle killer, creatine is a myostatin killer. Other studies have shown similar results ? that creatine is just what you want to take on myostatin.
There are many reasons to make creatine one of your main supplements, and this myostatin issue just adds to the impressive impact that creatine has on the muscles and the body. The myostatin advantage is one in a growing list of benefits that creatine supplementation brings to the table.

Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30. doi: 10.1016/j.mce.2009.12.019. Epub 2009 Dec 22.
Effects of oral creatine and resistance training on serum myostatin and GASP-1.
Saremi A1, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K.
Abstract
Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supp lementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.
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cristian2

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Re: Creatine Myostatin Study (ON INHIBITING MYOSTATIN) would be this TRUE ?
« Reply #1 on: September 19, 2017, 08:26:17 AM »

Another reason for me to be perma-taking creatine as natural.
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